By C K Cain
ANNUAL reviews IN MED CHEMISTRY V4 PPR.
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Presents evidence-based info, information and assistance on tips to behavior winning medications Use experiences (MURs). the 10 major chapters establish and talk about particular health conditions visible in group pharmacy whereas additional sub chapters comprise suggestion on treatment plans and correct sensible information.
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Additional info for Annual Reports in Medicinal Chemistry, 4
The guanidine I V showed a guanethidine type of hypot e n s i v e a c t i o n i n hypertensive dogst3 Blood pressure could b e c o n t r o l l e d without emesis and diarrhea i n t h e dogs--unlike guanethidine. 'c 1 V VI Intravenously i n c a t s , V (SD-15468) caused a b r i e f r i s e i n blood pressure followed by h y p o t e n s i o n of long duration during which responses t o norepinephrine were p o t e n t i a t e d and those t o c a r o t i d occlusion were reduced. Heart rate was slowed.
Peptides I n v e s t i g a t i o n of a series of s y n t h e t i c analogs of c a e r u l e i n ( I ) i n d i c a t e d t h a t their hypotensive and secretory effects are separable? SO3H I Py r Gln- Asp- Tyr T h r G 1y- T r p Met Asp -Ph-NH2 - - - - - I The s u l f a t e d t y r o s i n e r e s i d u e and t h e t h r e o n i n e ( o r replacement by methionine) are needed f o r good hypotensive e f f e c t . The f i r s t t h r e e amino a c i d s can be removed without major r e d u c t i o n i n a c t i v i t y .
3. Vet. Res. 29-), 869 (1968). 44. G. Chen, C. Ensor and B. Bohner, FederatGn Proc. 27, 706 (1968). 45. K. N. Salman, R. S. Rozman, H. F. Cascorbi and J. Krantz, Jr. Am. J. Vet. Res. 29(1), 165 (1968). 46. J. C. , B u l l . School Med. Univ. Maryland 52, 12 (1967). 47. B. M. S. Patent 3,362,874 (1968). 48. S. A. McDowell, K. D. H a l l and C. R. Stephen, B r i t . J. Anaesthesia 40, 511 (1968). 49. B. Dobkin, R. G. Heinrick, J. S. I s r a e l , A. A. Levy, 3. F. N e v i l l e and K. Ounkasem, Anesthesiology 29(2), 275 (1968).