Download Annual Reports in Medicinal Chemistry, 4 by C K Cain PDF

By C K Cain

ISBN-10: 0080583482

ISBN-13: 9780080583488


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The guanidine I V showed a guanethidine type of hypot e n s i v e a c t i o n i n hypertensive dogst3 Blood pressure could b e c o n t r o l l e d without emesis and diarrhea i n t h e dogs--unlike guanethidine. 'c 1 V VI Intravenously i n c a t s , V (SD-15468) caused a b r i e f r i s e i n blood pressure followed by h y p o t e n s i o n of long duration during which responses t o norepinephrine were p o t e n t i a t e d and those t o c a r o t i d occlusion were reduced. Heart rate was slowed.

Peptides I n v e s t i g a t i o n of a series of s y n t h e t i c analogs of c a e r u l e i n ( I ) i n d i c a t e d t h a t their hypotensive and secretory effects are separable? SO3H I Py r Gln- Asp- Tyr T h r G 1y- T r p Met Asp -Ph-NH2 - - - - - I The s u l f a t e d t y r o s i n e r e s i d u e and t h e t h r e o n i n e ( o r replacement by methionine) are needed f o r good hypotensive e f f e c t . The f i r s t t h r e e amino a c i d s can be removed without major r e d u c t i o n i n a c t i v i t y .

3. Vet. Res. 29-), 869 (1968). 44. G. Chen, C. Ensor and B. Bohner, FederatGn Proc. 27, 706 (1968). 45. K. N. Salman, R. S. Rozman, H. F. Cascorbi and J. Krantz, Jr. Am. J. Vet. Res. 29(1), 165 (1968). 46. J. C. , B u l l . School Med. Univ. Maryland 52, 12 (1967). 47. B. M. S. Patent 3,362,874 (1968). 48. S. A. McDowell, K. D. H a l l and C. R. Stephen, B r i t . J. Anaesthesia 40, 511 (1968). 49. B. Dobkin, R. G. Heinrick, J. S. I s r a e l , A. A. Levy, 3. F. N e v i l l e and K. Ounkasem, Anesthesiology 29(2), 275 (1968).

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