Download Antisense Therapeutics by Wafik S. El-Deiry PDF

By Wafik S. El-Deiry

ISBN-10: 1592598544

ISBN-13: 9781592598540

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The rate-limiting step in the RAS cascade is the conversion to the decapeptide Ang I. Increases in AGT production have been shown to have an effect on BP in both humans and experimental animals (9–11). Transgenic mice that produce high levels of Ang II are hypertensive (12–17), and hypertensive rat models have increased levels of Ang II (18–22). The spontaneously hypertensive rat (SHR) also has increased density of Ang II receptors (23,24). Human genetic studies have shown that the AGT gene is linked to hypertension.

L. (2000) Antiproliferative effects of steric blocking phosphorodiamidate Morpholino Antisense for Prevention of Restenosis 7. 7 8. 8 9. 9 10. 11. 11 12. 12 13. 13 14. 15. 16. 16 17. 17 18. 18 19. 19 49 antisense agents directed against c-myc. Antisense Nucleic Acid Drug Devel. 10, 163–176. , Blanchard, J. , and Jeanteur, P. (1984) Extreme instability of myc mRNA in normal and transformed human cells. Proc. Natl. Acad. Sci. USA 81, 7046–7050. Hann, S. R. and Eisenman, R. N. (1984) Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells.

2001) Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans. J. Am. Coll. Cardiol. 37, 175–182. , et al. (2001) Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension. Circulation 104, 346–351. Bloem, L. , Foroud, T. , Ambrosius, W. , et al. (1997) Association of the angiotensinogen gene to serum angiotensinogen in blacks and whites. Hypertension 29, 1078–1082.

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